UCHL1+ (CD45RO+)‘memory’T cells predominate in the CD4+ cellular infiltrate associated with allergen-induced late-phase skin reactions in atopic subjects

The skin microbiome in allergen-induced canine atopic dermatitis.

BACKGROUND Studies focusing on next-generation sequencing of the bacterial 16S rRNA gene have allowed detailed surveys of skin bacterial populations (microbiota) of the skin. HYPOTHESIS/OBJECTIVES This study evaluated temporal changes in the skin microbiota in a canine model of atopic dermatitis. ANIMALS Eight atopic dogs previously sensitized with house dust mites (HDM). METHODS The dogs...

Asthmatic Subjects Hyporesponsiveness in Atopic Allergic Induction of Antigen-Specific Late Asthmatic Reactions Precede the Allergen-Derived T Cell Peptide-Induced

Exercise-induced asthma and late phase reactions.

The hypothesis that respiratory heat loss was an initiating event in EIA was first proposed by CHEN and HoRTON [1) and later supported by McFADDEN et al. [2], who suggested that the severity of EIA is dependent upon the rapidity and magnitude of airway rewarming after exercise. It has been suggested that the airway cooling which results from hyperpnoea during exercise is followed by a rapid re-...

Evaluation of the Frequency of Food Allergens by Skin Prick Test in Children with Atopic Dermatitis

Background: The role of food allergy in atopic dermatitis (AD) is controversial. The aim of this study was to determine the frequency of food allergens in children with AD. Method: Fifty one atopic dermatitis children aged 6 months to 5 years entered our study. The severity of AD was determined by scoring index of AD (SCORAD). Skin prick test (SPT) was done using 15 allergens including the whit...

[Letter to the Editor] DNA Fragmentation Is Not Associated with Apoptosis in Zerumbone-induced HepG2 Cells

Zerumbone is a cytotoxic compound isolated from the herbal plant, Zingiber zerumbet Smith, which exhibits antitumor activity [1-2], anti-inflammatory effects and possesses anti-proliferative potentials in a variety of cell lines [3-4]. DNA fragmentation indicates an early event of apoptosis leading to cell death due to the absence of new cellular proteins synthesizing for cell survival. Previou...